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Related Concept Videos

Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Cleaning, Sterilization, and Disinfection01:30

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Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
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Related Experiment Video

Updated: Jul 8, 2025

Evaluation of the Efficacy of Organic Peroxyacids for Eradicating Dairy Biofilms Using an Approach Combining Static and Dynamic Methods
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Disinfectant caps in vitro effectiveness.

Sara Giordana Rimoldi1, Leyla La Cava2, Chiara Palladino3

  • 1Microbiology, Virology and Bioemergency Unit, ASST Fatebenefratelli Sacco, Milan, Italy.

Le Infezioni in Medicina
|December 11, 2023
PubMed
Summary

Disinfectant caps (DCs) effectively prevent catheter-related bloodstream infections (CRBSIs) by maintaining catheter lumen sterility. Both tested brands showed comparable efficacy, supporting their routine use in healthcare settings.

Keywords:
Catheter-related bloodstream infections (CRBSIs)Port Protectordisinfectant cap (DCs)in vitro modelneedle-free connectors (NFCs)

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Area of Science:

  • Infection Control
  • Medical Device Efficacy
  • Antimicrobial Technology

Background:

  • Catheter-related bloodstream infections (CRBSIs) pose significant risks to hospitalized patients.
  • Disinfectant caps (DCs) are increasingly recognized for their potential to reduce CRBSI rates.
  • Evaluating the efficacy of different DC manufacturers is crucial for infection prevention strategies.

Purpose of the Study:

  • To assess the in-vitro antiseptic efficacy of disinfectant caps (DCs) from two manufacturers.
  • To compare the effectiveness of these DCs under baseline and stress conditions.
  • To determine if significant differences exist between the two tested DC products.

Main Methods:

  • An in-vitro model was used to test thirteen different microorganisms.
  • Disinfectant effectiveness was evaluated with DCs on needle-free connectors (NFCs) and directly on catheter hubs.
  • Bacterial growth was assessed after incubation periods of 90 and 180 minutes.

Main Results:

  • Both DC manufacturers demonstrated effectiveness in baseline tests across fourteen assays.
  • Under stress conditions, significant bacterial load (Serratia marcescens) was observed only with one product (ICU Medical™) at specific time points.
  • Low bacterial loads for MDR Acinetobacter baumannii were noted for the other product (BD PureHub™).

Conclusions:

  • Results align with existing data for BD PureHub™ and provide new insights for ICU Medical™.
  • No significant difference in effectiveness was found between the two DC brands tested.
  • The routine use of DCs with NFCs is supported to reduce CRBSI incidence as part of comprehensive infection control bundles.