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Interaction of the viral infectious agents in the development and exacerbation of the multiple sclerosis

Sina Mahdavi1, Mahdi Asghari Ozma2, Arezou Azadi1

  • 1Department of Microbiology and Virology, Tabriz University of Medical Sciences, Tabriz, Iran.

Le Infezioni in Medicina
|December 11, 2023
PubMed

Insights

Viral infections may play a role in multiple sclerosis (MS), a central nervous system (CNS) disorder. This study explores potential molecular and genetic mechanisms linking viruses like EBV and HHV-6 to MS pathogenesis.

Area of Science:

  • Neurology
  • Immunology
  • Virology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS).
  • The exact cause of MS remains unknown, but genetic, environmental, and infectious factors are implicated.
  • Growing evidence suggests a potential role for viral infections in MS development.

Purpose of the Study:

  • To highlight proposed molecular and genetic mechanisms of viral interaction in MS pathogenesis.
  • To explore the implications of these viral interactions for MS development.

Main Methods:

  • Review and synthesis of existing literature on viral infections and MS.
  • Analysis of proposed molecular and genetic pathways involved in viral pathogenesis of MS.

Main Results:

  • Several viruses, including Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), and human endogenous retroviruses (HERVs), are proposed to be involved in MS pathogenesis.
  • Potential mechanisms include molecular mimicry, persistent infection, and immune dysregulation.
  • Genetic predisposition may interact with viral triggers.

Conclusions:

  • Viral infections represent a significant area of investigation for understanding MS etiology.
  • Further research into the specific molecular and genetic mechanisms is crucial for developing targeted therapies for MS.
Keywords:
Epstein-Barr VirusHuman Endogenous RetrovirusHuman Immunodeficiency VirusJohn Cunningham VirusMultiple Sclerosis

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