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Cerebral proliferative angiopathy in pediatric age presenting as neurological disorders: A case report
Fu-Ren Luo1, Ying Zhou2, Zhong Wang2
1Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Insights
Cerebral proliferative angiopathy (CPA) is rare in children, often presenting with neurological symptoms. This case highlights the need for better understanding and management of pediatric CPA.
Area of Science:
- Neurology
- Pediatric Neurology
- Vascular Neurology
Background:
- Cerebral proliferative angiopathy (CPA) is a rare arteriovenous malformation subtype.
- Pediatric CPA is exceptionally uncommon, posing diagnostic and therapeutic challenges.
- Limited global reports exist, lacking standardized diagnostic and treatment guidelines.
Observation:
- A 6-year-old presented with neurological dysfunction as the primary symptom of CPA.
- Digital subtraction angiography (DSA) confirmed the diagnosis.
- Conservative management with sedation, fluids, and anticoagulation was initiated.
Findings:
- The pediatric patient with CPA showed initial neurological symptoms.
- Conservative treatment was chosen due to high surgical risks and patient's age.
- No symptom exacerbation was observed during a 3-month follow-up.
Implications:
- This case contributes to the limited literature on pediatric CPA.
- Enhances understanding of congenital cerebrovascular diseases in children.
- Informs future clinical research and management strategies for pediatric CPA.
Background:
Cerebral proliferative angiopathy (CPA) is a rare subtype of arteriovenous malformation. It is extremely rare in pediatric patients and has serious implications for developing children. However, reports of these disorders worldwide are limited, and no uniform reference for diagnosis and treatment options exists. We report the case of a 6-year-old with CPA having predominantly neurological dysfunction and review the literature on pediatric CPA.
Case Summary:
We report the case of a pediatric patient with CPA analyzed using digital subtraction angiography (DSA) who presented initially with a neurological disorder as the main manifestation. This case is the basis for further discussion of the clinical presentation, pathogenesis, diagnosis, and treatment of CPA in children. After the cerebral DSA, the patient was treated conservatively with sedation, fluid replacement, and blood anticoagulation. She could not cooperate with the follow-up magnetic resonance imaging examination because of her young age, and her family declined further treatment because of the surgery's high risk. She was followed up for 3 months; her symptoms did not worsen.
Conclusion:
This report of rare pediatric CPA can inform and advance clinical research on congenital cerebrovascular diseases.
