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Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

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The causal relationship between gut microbiota and leukemia: a two-sample Mendelian randomization study.

Guanjun Chen¹, Zheshu Kuang¹, Fan Li²

¹Affiliated Hospital of Binzhou Medical University, Binzhou, China.

Frontiers in Microbiology

|December 11, 2023

Summary

This study used Mendelian randomization to find causal links between gut bacteria and leukemia. Certain bacteria increase leukemia risk, while others may be protective, offering new avenues for early detection and treatment.

Keywords:

acute lymphoblastic leukemia acute myeloid leukemia chronic lymphoblastic leukemia chronic myeloid leukemia gut microbiota leukemia mendelian randomization

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Microbiome research
Cancer genomics
Human genetics

Background:

The link between gut microbiota and leukemia is known, but causality is unproven.
Understanding this relationship is crucial for developing novel therapeutic strategies.

Purpose of the Study:

To investigate the causal relationship between gut microbial composition and leukemia risk.
To identify specific gut bacteria that act as risk or protective factors for different leukemia types.

Main Methods:

A bidirectional two-sample Mendelian randomization (MR) analysis was performed.
Utilized microbiome data (n=14,306) and leukemia data (n=1,145) from European populations.
Employed inverse variance weighted (IVW) method and sensitivity analyses with 5,742 instrumental variables (SNPs).

Main Results:

Ten gut microbial taxa were significantly associated with leukemia risk.
Genera Blautia and Lactococcus were identified as risk factors for acute lymphoblastic leukemia.
Several genera (Rikenellaceae RC9 gut group, Anaerostipes, Slackia, Lachnospiraceae ND3007 group, Ruminococcaceae UCG011, Ruminococcaceae UCG014) and one family (Acidaminococcaceae) were linked to increased or decreased risk for various leukemia subtypes, including acute myeloid leukemia and chronic myeloid leukemia.
Genus Slackia and family Acidaminococcaceae showed protective effects against specific leukemia types, while genus Desulfovibrio was protective for chronic lymphoblastic leukemia.

Conclusions:

Established a causal relationship between specific gut microbiota and leukemia development.
Identified potential pathogenic and probiotic bacteria relevant to leukemia.
Findings suggest novel targets for leukemia early detection, prevention, and treatment strategies.