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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Related Experiment Video

Updated: Jul 8, 2025

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
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Axillary lymph node pigmentation in tattooed patients.

Toshiyuki Yamaguchi1

  • 1Department of Surgery, Division of Breast Disease Asama Nanroku Komoro Medical Center Nagano Japan.

Clinical Case Reports
|December 11, 2023
PubMed
Summary
This summary is machine-generated.

Tattoo pigments can migrate to lymph nodes, potentially confusing cancer staging. Pathological examination confirmed tattoo pigment, not metastasis, in a sentinel lymph node biopsy.

Keywords:
lymph node pigmentationtattoo

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Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Tattoo pigments commonly migrate to regional lymph nodes.
  • This migration can mimic metastatic disease in lymph node biopsies.
  • Accurate lymph node staging is critical for breast cancer treatment.

Observation:

  • A patient with breast cancer had a tattoo near the surgical site.
  • The sentinel lymph nodes were biopsied during mastectomy.
  • One sentinel lymph node showed partial pink staining.

Findings:

  • Pathological examination revealed tattoo pigment particles within the stained lymph node.
  • No evidence of breast cancer metastasis was found in the examined lymph nodes.
  • The staining was definitively attributed to the tattoo pigment.

Implications:

  • Tattoo pigment in lymph nodes can lead to misinterpretation during cancer staging.
  • Awareness of tattoo pigment migration is crucial for surgeons and pathologists.
  • This case highlights the importance of correlating imaging and pathological findings.