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Microbacterium spp. peritonitis in patients undergoing peritoneal dialysis: a single-center experience and literature

Xiao Yu1,2, Zhao Li1, Xinbo Yang2

  • 1Department of Nephrology, Kidney Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Frontiers in Medicine
|December 11, 2023
PubMed
Abstract

Insights

Peritoneal dialysis-related peritonitis (PDRP) caused by Microbacterium spp. is rare. A 21-day antibiotic regimen combining vancomycin and meropenem shows promise for treating PDRP, with a high cure rate.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Microbiology

Background:

  • Peritoneal dialysis-related peritonitis (PDRP) caused by Microbacterium spp. is an uncommon complication.
  • Only 9 cases of Microbacterium spp. PDRP have been previously reported.
  • This study details treatment experiences for 7 patients with Microbacterium spp. PDRP.

Purpose of the Study:

  • To report treatment experiences of patients with Microbacterium spp. PDRP.
  • To evaluate the effectiveness of a specific antibiotic regimen for Microbacterium spp. PDRP.
  • To compare outcomes with previously reported cases.

Main Methods:

  • Retrospective collection of clinical data and antibiotic management for 7 PDRP episodes caused by Microbacterium spp.
  • Review of existing literature on Microbacterium spp. PDRP.
  • Analysis of empiric and adjusted antibiotic therapy, including intraperitoneal (IP) gentamicin, vancomycin, and meropenem.

Main Results:

  • Empiric therapy involved IP gentamicin and vancomycin, with gentamicin switched to meropenem if ineffective.
  • The intended antibiotic course was 21 days.
  • A total of 6 out of 7 episodes (85.7%) were cured, a higher rate than previously reported.

Conclusions:

  • A 21-day antibiotic therapy combining vancomycin and meropenem may be beneficial for managing Microbacterium spp. PDRP.
  • This treatment approach demonstrated a high cure rate in the studied patient cohort.
  • Further research may validate this regimen for rare PDRP cases.
Keywords:
Microbacterium spp.meropenemperitoneal dialysis (PD)peritonitisvancomycin

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