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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Updated: Jul 8, 2025

Pre-clinical Model of Cardiac Donation after Circulatory Death

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

Donor Evaluation Protocol for Live and Deceased Donors.

Pankaj Puri¹, Abhinav Kumar¹, Mohd Qaleem²

¹Fortis Escorts Liver and Digestive Diseases Institute, Fortis Escorts Hospital, New Delhi-110025, India.

Journal of Clinical and Experimental Hepatology

|December 11, 2023

Summary

Evaluating liver transplant donors is crucial for successful outcomes. This review covers essential factors for both living and deceased donors, including graft health and safety, to optimize transplantation success.

Keywords:

deceased donor liver transplantation donor evaluation donor selection liver transplantation living donor liver transplantation

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Last Updated: Jul 8, 2025

Pre-clinical Model of Cardiac Donation after Circulatory Death

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Published on: August 2, 2019

Study of Experimental Organ Donation Models for Lung Transplantation

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Published on: March 15, 2024

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

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Published on: August 15, 2022

Area of Science:

Transplantation Medicine
Hepatology
Surgical Research

Background:

Liver transplantation (LT) success hinges on meticulous donor selection.
Increasing use of extended-criteria or 'marginal donors' necessitates careful evaluation.
Living donor liver transplantation (LDLT) requires prioritizing donor safety.

Purpose of the Study:

To review critical factors in donor evaluation for liver transplantation.
To address considerations for both deceased donor LT (DDLT) and LDLT.
To emphasize the importance of graft quality and donor safety.

Main Methods:

Literature review of current practices in donor evaluation for LT.
Analysis of factors influencing graft viability and recipient outcomes.
Examination of risks associated with donor selection, including infection and malignancy transmission.

Main Results:

Donor evaluation is paramount for successful LT outcomes.
Graft health and the absence of transmitted diseases are key selection criteria.
Balancing organ scarcity with donor safety is essential, especially with marginal donors.

Conclusions:

Comprehensive donor evaluation is vital for optimizing liver transplant success.
Adherence to donor safety protocols is critical in LDLT.
Careful consideration of donor factors improves graft survival and patient prognosis.