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Myeloid Sarcoma: Case Series with Unusual Locations
Akram Abedi1, Nasrin Namdari2, Ahmad Monabati1
1Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
International Journal of Hematology-Oncology and Stem Cell Research
|December 11, 2023
Summary
Myeloid sarcoma (MS), a rare leukemia subtype, can present in unusual locations. Consider MS in high-grade tumors, especially with a history of myeloid neoplasms.
Area of Science:
- Hematology
- Oncology
Background:
- Myeloid sarcoma (MS), also known as chloroma, is a granulocytic tumor and a subtype of acute myeloid leukemia (AML).
- MS typically occurs as a complication of AML, myelodysplastic syndrome, or myeloproliferative disorders, affecting 2.5-9.1% of AML patients.
- It can precede, coincide with, or occur at relapse of hematologic disorders, and rarely, present without evidence of them.
Observation:
- This study presents seven cases of myeloid sarcoma with unusual locations or rare presentations.
- These cases highlight the diverse clinical manifestations of MS.
- The observations underscore the importance of considering MS in specific diagnostic contexts.
Findings:
- Myeloid sarcoma can manifest in extranodal sites and present atypically.
- The study identified rare presentations of MS at initial diagnosis or relapse.
- These findings expand the understanding of MS's clinical spectrum.
Implications:
- Myeloid sarcoma should be included in the differential diagnosis of high-grade tumors.
- Early consideration of MS is crucial, particularly in patients with a history of myeloid neoplasms.
- Recognizing rare presentations aids in timely diagnosis and management of myeloid sarcoma.
