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Cytoskeletal Coordination in Cell Migration

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...

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Related Experiment Video

Updated: Jul 8, 2025

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

Length control emerges from cytoskeletal network geometry.

Shane G McInally¹, Alexander J B Reading², Aldric Rosario³

¹Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, 01609, USA.

Biorxiv : the Preprint Server for Biology

|December 11, 2023

Summary

This summary is machine-generated.

Yeast cells control actin cable length through filament organization, not feedback. This emergent property allows cables to scale with cell size by adjusting formin activity.

Keywords:

Biological scaling Biological sciences Cell biology Cytoskeleton Emergence Size control

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Last Updated: Jul 8, 2025

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

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Published on: March 10, 2023

Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators

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Published on: May 12, 2018

Directly Measuring Forces Within Reconstituted Active Microtubule Bundles

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Published on: May 10, 2022

Area of Science:

Cell biology
Biophysics
Cytoskeletal dynamics

Background:

Cytoskeletal networks, crucial for cell function, are organized into higher-order structures.
Previous research focused on filament turnover feedback for cytoskeletal assembly control.
Actin cables in yeast are vital higher-order structures with poorly understood length regulation.

Conclusions:

A new paradigm for cytoskeletal higher-order structure control is proposed.
Emergent properties of filament organization are key to actin cable length regulation.
Cell size directly influences actin cable length through formin activity modulation.