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Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

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Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

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Improved Quantification of MicroPET/CT Imaging Using CT-derived Scaling Factors.

Ayon Nandi¹, Masayoshi Nakano², James Robert Brašić³

¹Johns Hopkins School of Medicine: The Johns Hopkins University School of Medicine.

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|December 11, 2023

Summary

CT-based coregistration (PTCT) improves brain dimension accuracy in rodent micro-PET/CT studies. This method enhances nondisplaceable binding potential (BPND) estimates compared to conventional PET-based coregistration.

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Area of Science:

Neuroscience
Medical Imaging
Pharmacology

Background:

Combined micro-PET/CT scanners are essential for studying rodent brain disorders.
Accurate coregistration is crucial for reliable PET data analysis, particularly for estimating binding potentials.

Conclusions:

Conventional PET-based coregistration can introduce bias in BPND estimates, especially when using the cerebellum as a reference region.
The proposed CT-based coregistration (PTCT) offers quantitative improvements for rodent brain studies using micro-PET/CT.