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Improved Quantification of MicroPET/CT Imaging Using CT-derived Scaling Factors
Ayon Nandi1, Masayoshi Nakano2, James Robert Brašić3
1Johns Hopkins School of Medicine: The Johns Hopkins University School of Medicine.
Research Square
|December 11, 2023
Summary
CT-based coregistration (PTCT) improves brain dimension accuracy in rodent micro-PET/CT studies. This method enhances nondisplaceable binding potential (BPND) estimates compared to conventional PET-based coregistration.
Area of Science:
- Neuroscience
- Medical Imaging
- Pharmacology
Background:
- Combined micro-PET/CT scanners are essential for studying rodent brain disorders.
- Accurate coregistration is crucial for reliable PET data analysis, particularly for estimating binding potentials.
Conclusions:
- Conventional PET-based coregistration can introduce bias in BPND estimates, especially when using the cerebellum as a reference region.
- The proposed CT-based coregistration (PTCT) offers quantitative improvements for rodent brain studies using micro-PET/CT.
