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Pan-Cancer Analysis of the Cuproptosis-Related Gene DLD
Jiahui Lin1, Guowei Wang2, Sha Cheng1
1Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
The dihydrolipoamide dehydrogenase (DLD) gene is linked to various cancer prognoses and plays a role in tumor metabolism and immunity. Its expression and potential as a drug target are explored across multiple cancer types.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genomics
Background:
- Cancer poses a significant global health and economic burden.
- Cuproptosis is a newly identified cell death pathway.
- The role of dihydrolipoamide dehydrogenase (DLD), a cuproptosis-related gene, in pan-cancer remains unclear.
Purpose of the Study:
- To investigate the expression, prognostic, and diagnostic value of DLD in pan-cancer.
- To explore the association of DLD with the tumor immune microenvironment.
- To identify potential therapeutic targets related to DLD.
Main Methods:
- Utilized data from GTEx, TCGA, and online databases.
- Assessed DLD expression, prognosis, and diagnostic utility across various tumors.
- Analyzed correlations between DLD and immune factors, TMB, MSI, and drug sensitivity.
Main Results:
- DLD expression varies significantly across most cancers and is linked to prognosis in KIRC, KIRP, KICH, and UCS.
- DLD demonstrates strong diagnostic value in KIRC, GBM, PAAD, and LGG.
- DLD expression correlates with immune cell infiltration, immunomodulators, immune checkpoints, TMB, and MSI, and potential drug targets were identified.
Conclusions:
- DLD expression is integral to tumorigenesis, tumor metabolism, and immunity.
- DLD is associated with diverse tumor prognoses and presents potential therapeutic avenues.
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