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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

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Receptor tyrosine kinases: biological functions and anticancer targeted therapy

Nan Zhang1, Yongsheng Li1,2

  • 1Chongqing University Cancer Hospital, School of Medicine Chongqing University Chongqing China.

Medcomm
|December 11, 2023
PubMed

Insights

Receptor tyrosine kinases (RTKs) are vital for cell functions and cancer development. Targeted therapies show promise, but optimizing RTK inhibitors is crucial for effective cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Receptor tyrosine kinases (RTKs) are key regulators of cellular processes like growth and angiogenesis.
  • Dysregulated RTKs are implicated in tumor progression, metastasis, and cancer stem cell self-renewal.
  • Targeted therapies offer potential benefits for cancer patients with RTK alterations.

Purpose of the Study:

  • To review the classification, structure, and activation mechanisms of RTKs.
  • To highlight advances in RTK-targeted anticancer therapies.
  • To emphasize the role of RTKs in cancer diagnosis and treatment optimization.

Main Methods:

  • Literature review of RTK classification and function.
  • Analysis of RTK roles in tumor biology.
  • Summary of current RTK-targeted therapy research and development.

Main Results:

  • 58 human RTKs exist in 20 families, activated by specific ligands.
  • RTKs regulate critical cancer hallmarks, including proliferation and angiogenesis.
  • RTK-targeted therapies are advancing, but inhibitor optimization is needed.

Conclusions:

  • Understanding RTK biology is essential for cancer diagnosis and treatment.
  • RTK-targeted therapies represent a significant advancement in oncology.
  • Further research is needed to refine RTK inhibitors for diverse cancer alterations.
Keywords:
classificationgene mutationreceptor activationreceptor tyrosine kinasestargeted therapy

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