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Guillain-Barré Syndrome Associated with COVID-19: Is There A Causal Relation or Just A Coincidence?
1Departments of Neurology and Clinical Neurophysiology, Faculty of Medicine, Istanbul University, İstanbul, Turkey.
Insights
The link between Coronavirus disease 19 (COVID-19) and Guillain-Barré syndrome (GBS) is investigated. While some studies show increased GBS incidence during the pandemic, the causal relationship remains controversial, requiring further research.
Area of Science:
- Neurology
- Infectious Diseases
- Epidemiology
Background:
- The Coronavirus disease 19 (COVID-19) pandemic has been associated with Guillain-Barré syndrome (GBS) reports.
- Several case reports and series explore a potential causal link between COVID-19 and GBS.
Abstract:
After the outbreak of Coronavirus disease 19 (COVID-19), several case reports and case series of Guillain-Barré syndrome (GBS) associated with COVID-19 have been published to unravel the possible causal link between GBS and COVID-19. In this brief report, the epidemiological data from regions in different countries was reviewed. Some studies report an increase in the incidence of GBS during the pandemic while the others do not. The clinical features of GBS associated with COVID-19 was older age, male predominance, and typical sensorimotor variant responding well to treatments. The most common electrodiagnostic subtype was demyelinating. Despite the high effort, the causal relation between COVID-19 and GBS remains controversial. Case-control studies with high number of patients are needed to understand the relation between GBS and COVID-19.
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