Related Experiment Video
Updated: Jul 8, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
12.3K
Circular RNAs: emerging players in asthma and COPD
Xiaoying Liu1, Md Khadem Ali2, Kamal Dua3,4,5
1Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Frontiers in Cell and Developmental Biology
|December 11, 2023
Summary
Circular RNAs (circRNAs) are novel molecules involved in asthma and COPD. This review explores their function and potential as biomarkers for these chronic respiratory diseases.
Area of Science:
- * Molecular biology
- * RNA biology
- * Respiratory medicine
Background:
- * Circular RNAs (circRNAs) are non-coding RNAs with a unique circular structure.
- * circRNAs regulate gene expression by interacting with microRNAs and RNA-binding proteins.
- * They influence cellular processes like proliferation, migration, and inflammation.
Purpose of the Study:
- * To review the role of circRNAs in the pathogenesis of asthma and COPD.
- * To explore the molecular mechanisms underlying circRNA function in these diseases.
- * To discuss the potential of circRNAs as diagnostic and prognostic biomarkers for asthma and COPD.
Main Methods:
- * Literature review of studies on circRNAs in asthma and COPD.
- * Analysis of circRNA expression patterns and functional roles in airway and immune cells.
- * Examination of circRNA involvement in cellular processes relevant to asthma and COPD.
Main Results:
- * Altered circRNA expression is implicated in asthma pathogenesis, affecting cell proliferation, migration, and inflammation.
- * circRNAs play a role in COPD by modulating inflammation, oxidative stress, and airway remodeling.
- * circRNAs show potential as biomarkers for diagnosing and predicting outcomes in asthma and COPD.
Conclusions:
- * circRNAs are key players in the molecular mechanisms of asthma and COPD.
- * circRNAs represent promising therapeutic targets and diagnostic/prognostic biomarkers for respiratory diseases.
- * Further research is needed to fully elucidate the clinical utility of circRNAs in asthma and COPD management.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:22Chronic Obstructive Pulmonary Disease
1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K
01:20Asthma: Pathogenesis and Management
411
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
411