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Sebastian Vigand Svendsen1, Natascha Gk Lange1, Morten J Christensen1

  • 1Hudafdeling I og Allergicentret, Odense Universitetshospital.

Ugeskrift for Laeger
|December 11, 2023
PubMed
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Urticaria, a common skin condition, involves mast cell activation causing hives and swelling. Chronic spontaneous urticaria often has autoimmune causes, impacting quality of life and requiring targeted treatments.

Area of Science:

  • Dermatology
  • Immunology
  • Allergy

Background:

  • Urticaria is a common skin condition characterized by mast cell activation, leading to wheals and/or angioedema.
  • Acute urticaria (≤ 6 weeks) is linked to infections and allergies.
  • Chronic urticaria (≥ 6 weeks) is classified as spontaneous (CSU), inducible, or both, frequently impairing patients' quality of life (QoL).

Approach:

  • This review focuses on the management of urticaria, particularly chronic spontaneous urticaria (CSU).
  • The pathogenesis of CSU is frequently autoimmune.
  • Treatment strategies aim to improve QoL through a stepwise approach.

Key Points:

  • CSU pathogenesis is often autoimmune.
  • Treatment aims to restore QoL.

Related Experiment Videos

  • Stepwise treatment typically involves second-generation H1-antihistamines, omalizumab, and cyclosporine.

    • Conclusions:

    • Urticaria management prioritizes restoring patient quality of life.
    • A stepwise therapeutic strategy is essential for effective urticaria treatment.
    • Pharmacological interventions include antihistamines, omalizumab, and cyclosporine for refractory cases.