Related Experiment Video
Updated: Jul 8, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Sick leave due to SARS-CoV-2 infection
G Vandersmissen1, J Verbeeck2, P Henckens3
1IDEWE, External Service for Prevention and Protection at Work, 3001 Heverlee, Belgium.
Long-term sick leave due to COVID-19 (Coronavirus disease 2019) was less prevalent than anticipated in Belgian workers. Factors like older age and prior sick leave influenced prolonged absences, but overall rates were lower than initial concerns suggested.
Area of Science:
- Occupational Health
- Epidemiology
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) has led to significant sick leave globally.
- The duration of COVID-19 related sick leave, particularly long-term absences (>12 weeks), requires further investigation.
- Uncertainty exists regarding the true impact of long COVID on workforce absenteeism.
Purpose of the Study:
- To assess the burden of sick leave, especially long-term (>12 weeks), among Belgian workers testing positive for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).
- To compare long-term sick leave data for COVID-19 with that of other infectious diseases.
- To identify predictors of prolonged sickness absence in workers with COVID-19.
Main Methods:
- Utilized a combined database of SARS-CoV-2 positive workers and those absent for other infections, linked to objective absence records.
- Employed negative binomial regression, Cox proportional hazards regression, and ordinal logistic regression to analyze predictors of prolonged sickness.
- Included 2569 SARS-CoV-2 positive workers and 392 workers with other infectious diseases in the analysis.
Main Results:
- Among workers with COVID-19, 16% had no registered sick leave.
- The incidence of sick leave exceeding 12 weeks was 14 per 1000 workers for COVID-19, compared to 43 per 1000 for other infections.
- When accounting for all positive cases (including those with no sick leave), the long-term sick leave prevalence for COVID-19 was 12 per 1000.
- Prolonged sick leave was associated with older age, a history of high sick leave, and lower educational attainment.
Conclusions:
- The prevalence of long-term sick leave associated with COVID-19 was lower than suggested by earlier studies.
- Despite concerns about post-COVID-19 syndrome, the study indicates a lower-than-expected burden of prolonged absenteeism.
- Findings highlight the importance of considering all absence data, including zero sick leave, for accurate prevalence estimates.
Related Concept Videos
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Stages of Infection
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Sputum Studies II: Culture and Sensitivity
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Classification of Illness
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...

