Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

5.5K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.5K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

170
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
170
Endocrine Signaling01:45

Endocrine Signaling

64.4K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
64.4K
Development of Blood Vessels01:07

Development of Blood Vessels

594
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
594
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genes, other than Muc5b, are associated with bleomycin-induced lung injury.

Communications biology·2026
Same author

The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development.

Development (Cambridge, England)·2025
Same author

The Society for Craniofacial Genetics and Developmental Biology 47th Annual Meeting.

American journal of medical genetics. Part A·2025
Same author

The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development.

bioRxiv : the preprint server for biology·2024
Same author

The society for craniofacial genetics and developmental biology 46th annual meeting.

American journal of medical genetics. Part A·2024
Same author

The Society for Craniofacial Genetics and Developmental Biology 45th Annual Meeting.

American journal of medical genetics. Part A·2023
Same journal

Dissecting planar and vertical organiser signals in early chick neural development.

Development (Cambridge, England)·2026
Same journal

Real-time transcriptomic profiling of hPSC-derived cartilage during development identifies a key role for the extracellular matrix in homeostasis and protection.

Development (Cambridge, England)·2026
Same journal

In preprints - housekeeping the housekeeping genes.

Development (Cambridge, England)·2026
Same journal

In preprints - light, cluster, friction: a cell dance on the gastrulation stage.

Development (Cambridge, England)·2026
Same journal

PBX-dependent and -independent Hox programs establish and maintain motor neuron terminal identity.

Development (Cambridge, England)·2026
Same journal

NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity.

Development (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Jul 8, 2025

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

11.3K

Endothelin signaling in development.

Stanley M Kanai1, David E Clouthier1

  • 1Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Development (Cambridge, England)
|December 11, 2023
PubMed
Summary
This summary is machine-generated.

Endothelin signaling is vital for neural crest development, not just blood pressure. Understanding its role in development offers insights into genetic disorders and potential treatments.

Keywords:
Auriculocondylar syndromeCardiovascularCraniofacialEntericG proteinHirschsprung diseaseMelanocyte

More Related Videos

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

8.5K
Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
04:23

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

2.2K

Related Experiment Videos

Last Updated: Jul 8, 2025

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

11.3K
Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

8.5K
Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
04:23

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

2.2K

Area of Science:

  • Developmental Biology
  • Endocrinology
  • Genetics

Background:

  • Endothelin 1 (EDN1) and its receptors are well-studied for blood pressure regulation.
  • Endothelin signaling also critically influences neural crest cell development.
  • Dysregulation of this pathway is linked to human developmental syndromes.

Approach:

  • Utilizes in vivo and in vitro methods to study endothelin s role.
  • Deciphers mechanisms of endothelin action in neural crest maturation.
  • Reviews existing literature on endothelin pathway functions.

Key Points:

  • Endothelin pathway is essential for neural crest-derived tissue formation.
  • Altered endothelin signaling underlies specific developmental differences.
  • Research elucidates genetic bases for syndromes related to endothelin variants.

Conclusions:

  • Endothelin signaling's developmental roles are increasingly understood.
  • Knowledge of endothelin pathway dysfunction can inform therapeutic strategies.
  • Potential treatments for genetic variants affecting endothelin signaling are being explored.