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Related Experiment Video

Updated: Jun 13, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Reduced Reward Processing in Schizophrenia: A Comprehensive EEG Event-Related Oscillation Study.

Özge Akgül¹, Ezgi Fide², Fatih Özel³

¹Department of Psychology, Faculty of Arts and Sciences, İzmir Democracy University, Izmir, Turkey.

Brain Topography

|December 11, 2023

Summary

Schizophrenia (SZ) patients exhibit altered brain activity during reward anticipation, showing reduced delta, theta, beta, and gamma oscillations. These findings highlight disrupted neural dynamics in reward processing for schizophrenia, potentially informing new treatments.

Keywords:

Anhedonia Event-related oscillations High-frequency Low-frequency Reward processing Schizophrenia

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Last Updated: Jun 13, 2026

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Published on: November 19, 2014

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Published on: May 31, 2018

Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Abnormal reward processing is a hallmark of psychiatric disorders, including schizophrenia (SZ).
Reduced reward anticipation is considered a core symptom in SZ.
Event-related oscillations (EROs) offer insights into neural activity during cognitive tasks.

Purpose of the Study:

To investigate EROs across delta, theta, alpha, beta, and gamma frequency bands in SZ patients.
To compare EROs during a reward anticipation task (Monetary Incentive Delay task) between SZ patients and healthy controls.
To explore correlations between EROs and clinical symptoms in SZ.

Main Methods:

Twenty-one patients with SZ and twenty-two healthy controls participated.
Participants completed the Monetary Incentive Delay (MID) task.
EROs were analyzed and compared between groups; correlation analyses were performed with clinical scores.

Main Results:

SZ patients showed reduced delta and theta amplitudes in the reward condition compared to controls.
Reduced beta amplitudes (total and non-incentive cue-related) and frontal gamma amplitudes (incentive cue-related) were observed in SZ.
SZ patients exhibited higher incentive cue-related theta and occipital gamma amplitudes; theta correlated with depression and impulsivity.

Conclusions:

This study provides the first comprehensive evidence of widespread ERO impairments (delta to gamma) in SZ during reward anticipation.
Findings suggest impaired dopaminergic neurotransmission, disrupted cognitive functioning, and potential links to negative symptoms in SZ.
Understanding these disrupted brain dynamics in reward processing may pave the way for innovative rehabilitation strategies for schizophrenia.