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Titanium Dioxide Nanoparticles Induce Cell Cycle Arrest and Apoptosis through Inhibiting PI3K/AKT/mTOR Pathway in

Ruoyun Dong1, Xiaojia Meng2, Hongmei Chang1

  • 1Department of Preventive Medicine / the Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the Xinjiang Production and Construction Corps, School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang, China.

Biological Trace Element Research
|December 11, 2023
PubMed
Summary

Titanium dioxide nanoparticles (TiO2 NPs) harm sperm production by causing cell cycle arrest and apoptosis in spermatogonia. This occurs via the PI3K/AKT/mTOR pathway, explaining reduced sperm counts.

Keywords:
ApoptosisCell cycleGC-1 cellsPI3K/AKT/mTOR pathwayTitanium dioxide nanoparticles

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