Related Experiment Video
Updated: Jul 8, 2025
04:56
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
Published on: August 4, 2023
775
Treatments for Trauma-Induced Coagulopathy: Protocol for a Systematic Review and Meta-Analysis
Yuki Itagaki1, Mineji Hayakawa1,2, Yuki Takahashi1
1Department of Emergency Medicine, Hokkaido Univerisity, Sapporo, Japan.
JMIR Research Protocols
|December 11, 2023
Summary
This systematic review evaluates interventions for trauma-induced coagulopathy (TIC), a bleeding disorder from severe injury. It synthesizes evidence on treatments like tranexamic acid and blood products to improve patient outcomes.
Area of Science:
- Trauma and Emergency Medicine
- Hematology and Coagulation Disorders
- Evidence Synthesis and Meta-Analysis
Background:
- Trauma-induced coagulopathy (TIC) is a critical condition characterized by abnormal blood clotting and bleeding following severe injury.
- Current treatments for TIC lack clear evidence regarding their effectiveness and safety.
- A comprehensive synthesis of existing research on TIC management is necessary.
Purpose of the Study:
- To systematically review and meta-analyze the effectiveness and safety of interventions for managing trauma-induced coagulopathy (TIC).
- To evaluate treatments including coagulation factor concentrates, tranexamic acid, and blood component products.
Main Methods:
- Systematic review and meta-analysis of randomized and nonrandomized controlled trials, plus observational studies on severe trauma patients with TIC.
- Searched MEDLINE (PubMed), Web of Science, and Cochrane Central Register of Controlled Trials.
- Assessed risk of bias using the Cochrane tool and strength of evidence with GRADE.
Main Results:
- Study selection summarized using a PRISMA flowchart.
- Evidence presented in tables and figures, including forest plots for meta-analysis results.
- Primary outcome is in-hospital mortality.
Conclusions:
- This review will provide updated evidence on the efficacy and safety of key interventions for TIC.
- It aims to be the first systematic review and meta-analysis specifically focused on TIC management.
- Findings will inform clinical practice for treating trauma-induced coagulopathy.
Related Concept Videos
01:20Extrinsic and Intrinsic Pathways of Hemostasis
7.9K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.9K
01:05Introduction to Hemostasis
8.0K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.0K
01:09Coagulation
6.8K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
6.8K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
708
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
708