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Updated: Jul 8, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

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Longitudinal development of central SBP in children with congenital heart disease

Laura Willinger1,2, Leon Brudy1, Michael Meyer1

  • 1Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum München.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|December 11, 2023
PubMed

Insights

Central systolic blood pressure (cSBP) significantly increases over time in children with congenital heart disease (CHD). This longitudinal rise in cSBP warrants further investigation and focused monitoring in specific patient groups.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Physiology
  • Longitudinal Health Studies

Background:

  • Central systolic blood pressure (cSBP) is elevated in children with congenital heart disease (CHD).
  • The developmental trajectory of cSBP over time in pediatric CHD populations has not been previously studied.

Purpose of the Study:

  • To longitudinally assess the natural course of cSBP in children and adolescents diagnosed with CHD.
  • To identify factors influencing the progression of cSBP in this cohort.

Main Methods:

  • A prospective longitudinal study involving 306 children and adolescents with CHD.
  • Noninvasive oscillometric measurement of cSBP over a mean follow-up of 30.1 months.
  • Analysis using a linear mixed-effects model to determine cSBP trends.

Main Results:

  • cSBP demonstrated a significant annual increase of 1.22 mmHg in children with CHD.
  • This increase remained significant after adjusting for sex, BMI, medication, disease severity, and CHD type.
  • Higher cSBP increases were observed in patients with transposition of the great arteries (TGA) post-arterial switch, obese children, and boys.

Conclusions:

  • This study confirms a significant longitudinal increase in cSBP among children with CHD.
  • Further research is needed to determine if these cSBP trajectories are abnormal.
  • Monitoring vascular function, particularly in TGA patients and obese children with CHD, is recommended.
Abstract

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