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Updated: Jul 8, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Interleukin-6 serum levels are associated with disease features and cardiovascular risk in patients with systemic
Zeina Ibrahim-Achi1, Antonia de Vera-González2, Alejandra González-Delgado2
1Division of Angiology and Vascular Surgery, Hospital Universitario de Canarias, Tenerife, Spain.
Objectives:
Systemic sclerosis (SSc) is a chronic multisystem disease characterised by microcirculatory vascular dysfunction and progressive fibrosis of the skin and internal organs. Interleukin-6 (IL-6) is a proinflammatory cytokine that has been implicated in the pathogenesis of several autoimmune diseases and in the initiation and progression of the cardiovascular disease. In the present work we aimed to study the relationship of IL-6 with clinical manifestations and the cardiovascular risk in patients with SSc.
Methods:
We carried out a cross-sectional study that included 53 individuals with SSc. A multivariate analysis was performed to study the relationship between IL-6 and disease characteristics and cardiovascular risk assessed by Systematic Coronary Risk Estimation (SCORE2) in SSc.
Results:
The presence of digital ulcers, calcinosis, and anti-Scl70 antibody was associated with higher levels of IL-6. This was also the case for functional respiratory parameters where this association was found to be significant and negative after correction for covariates. In addition, the SCORE2 cardiovascular risk algorithm showed a positive and significant association with circulating IL-6.
Conclusions:
IL-6 levels are associated with disease manifestations and cardiovascular risk in patients with SSc.
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