[Methanol poisoning. Clinical, neuropathologic and computerized tomography findings]

Area of Science:

• Neurology
• Toxicology
• Pathology

Background:

• Acute methanol intoxication presents a significant toxicological challenge.
• Understanding its clinical and pathological manifestations is vital for patient outcomes.

Observation:

• Two case reports detail clinical, CT-scan, and neuropathological findings in methanol poisoning.
• A rare complication, hemorrhagic leukoencephalopathy, developed after a latency period in one patient.

Findings:

• Acidosis is a critical factor influencing survival rates and late sequelae in methanol intoxication.
• Striking CT-scan and morphological features characterized the hemorrhagic leukoencephalopathy.

Implications:

• Therapeutic strategies include correcting acidosis, hemodialysis, and administering ethanol and folic acid.
• This study highlights the importance of prompt and comprehensive management for methanol intoxication and its complications.