Related Experiment Video

Updated: Jul 8, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

925

Precision Oncology: 2023 in Review

Yonina R Murciano-Goroff1, Sarah P Suehnholz2,3, Alexander Drilon1,4

  • 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Cancer Discovery
|December 12, 2023
PubMed
Abstract

Insights

Precision oncology has seen major advances, with new drugs and biomarkers identified. Improved clinical trial designs are accelerating the testing of these targeted cancer therapies.

Area of Science:

  • Oncology
  • Genomics
  • Clinical Pharmacology

Background:

  • Precision oncology leverages molecular profiling to tailor cancer treatments.
  • Significant progress has been made in identifying targetable mutations and developing corresponding therapies.

Approach:

  • This review synthesizes recent advancements in precision oncology from late 2022 through 2023.
  • It examines various classes of precision oncology drugs and their companion biomarkers.
  • Improvements in clinical trial methodologies for efficient drug evaluation are discussed.

Key Points:

  • Identification of novel drug classes and biomarkers driving precision oncology.
  • Enhanced understanding of molecular mechanisms underlying cancer treatment response.
  • Evolution of adaptive and biomarker-driven clinical trial designs.

Conclusions:

  • Recent advances are rapidly expanding the scope and efficacy of precision oncology.
  • Future implications include more personalized and effective cancer care strategies.
  • Continued integration of biomarker discovery and innovative trial designs is crucial for future progress.

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