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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
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Characterizing close-focus lenses for microendoscopy.

Dominique Galvez1, Zhihan Hong1, Andrew D Rocha1

  • 1University of Arizona, Wyant College of Optical Sciences, Tucson, United States of America.

Journal of Optical Microsystems
|December 12, 2023
PubMed
Summary
This summary is machine-generated.

3D printed micro-optics offer high-performance, close-focus imaging for microendoscopy. Custom 3D printed triplets and doublets provide superior optical solutions for small lumen navigation and disease detection in aqueous environments.

Keywords:
3D printingEndoscopyLens designmicroendoscopemulti-modal imaging

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Area of Science:

  • Optical engineering
  • Medical imaging technology
  • Additive manufacturing

Background:

  • Microendoscopes require distal optics for navigation and disease detection in small body lumens.
  • Existing micro-optic systems (below 1mm) have limitations in performance and cost, while GRIN singlets offer limited adjustability.
  • 3D printed monolithic optical systems present a promising alternative for high-performance, close-focus imaging.

Purpose of the Study:

  • To compare the optical performance of custom distal optic systems for microendoscopy.
  • To evaluate gradient index (GRIN) singlets against 3D printed monolithic doublets and triplets.
  • To assess the suitability of 3D printing for creating short working distance (WD) micro-optics in saline.

Main Methods:

  • Designed and fabricated three custom distal optic systems: a GRIN singlet, a 3D printed doublet, and a 3D printed triplet.
  • Tested optical performance in 0.9% saline with nominal working distances of 1.5mm, 0.5mm, and 0.4mm respectively.
  • Evaluated depth of field (DOF) for each system to determine imaging capabilities.

Main Results:

  • The GRIN singlet's performance was limited by the fiber bundle relay, with a depth of field (DOF) of 0.9mm to 1.6mm.
  • The 3D printed doublet achieved a comparable DOF of 0.71mm.
  • The 3D printed triplet exhibited the most limited DOF at 0.55mm, despite its short working distance.

Conclusions:

  • 3D printing allows flexible design of monolithic multi-element micro-optic systems with aspheric surfaces.
  • 3D printed optics enable very short working distances crucial for microendoscopy in collapsed lumens.
  • Additive manufacturing offers a viable and adaptable approach for developing advanced microendoscopic imaging systems.