Susceptibility of MMP3 gene polymorphism to coronary artery disease: A meta-analysis

Area of Science:

• Genetics and Cardiovascular Disease Research
• Molecular Biology and Disease Mechanisms

Background:

• The association between the MMP3-1612 5A/6A polymorphism and coronary artery disease (CAD) risk remains debated.
• Existing research presents conflicting conclusions regarding this genetic susceptibility.

Purpose of the Study:

• To conduct a comprehensive meta-analysis to establish the precise relationship between the MMP3-1612 5A/6A polymorphism and the risk of developing CAD.
• To resolve controversies surrounding the genetic predisposition to CAD conferred by this specific matrix metalloproteinase 3 (MMP3) variant.

Main Methods:

• A systematic literature search was performed across major databases (PubMed, Web of Science, Cochrane Library, CNKI, VIP, Wanfang) for studies published before July 2019.
• Data from 18 eligible studies examining the MMP3-1612 5A/6A polymorphism and CAD were extracted independently by two researchers.
• Statistical analysis, including odds ratio (OR) and 95% confidence interval (CI) calculation, was performed using RevMan 5.3 and STATA 12.0.

Main Results:

• The meta-analysis synthesized data from 18 relevant studies.
• Odds ratios and 95% confidence intervals were calculated to quantify the association.
• Disagreements in data extraction were resolved by a third researcher to ensure accuracy.

Conclusions:

• The meta-analysis provides a synthesized view on the controversial link between MMP3-1612 5A/6A and CAD risk.
• The study aims to offer a more definitive conclusion on the genetic susceptibility conferred by this polymorphism.
• Further research may be warranted to fully elucidate the role of MMP3-1612 5A/6A in CAD pathogenesis.