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Updated: Jul 8, 2025
04:44
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
284
Brain functional changes across mood states in bipolar disorder: from a large-scale network perspective
Yan-Kun Wu1, Yun-Ai Su1, Le Li2,3
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Psychological Medicine
|December 12, 2023
Summary
Bipolar disorder (BD) involves altered brain network connectivity, particularly the default mode network (DMN), during manic states. These changes correlate with mania severity, offering insights into BD
Area of Science:
- Neuroscience
- Psychiatry
- Brain Imaging
Background:
- Understanding the neural basis of mood states is crucial for bipolar disorder (BD) pathophysiology.
- Research on mood switching in BD has been limited and inconsistent.
Purpose of the Study:
- To investigate large-scale brain network functional connectivity (FC) differences across mood states in bipolar disorder.
- To correlate these network alterations with clinical characteristics.
Main Methods:
- Resting-state fMRI data from 162 BD patients (manic, euthymic, depressive) and 80 healthy controls (HCs).
- Comparison of large-scale brain network FC and topological nodal properties.
- Validation using a small longitudinal sample (n=11).
Main Results:
- (Hypo)manic patients showed strengthened network FC, especially involving the default mode network (DMN), compared to HCs and other BD states.
- Increased FC between DMN and ventral attention/limbic networks correlated with (hypo)mania severity and positive affect.
- Bipolar depressive patients exhibited decreased FC within the limbic network (LN).
Conclusions:
- Identified a distinct pattern of large-scale network disturbances in (hypo)mania within bipolar disorder.
- These findings enhance understanding of the neural mechanisms underlying mood states in BD.
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