Markedly Increased Mean Platelet Volume in Bacterial Meningitis

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Young Jin Kim, Kyung Sun Park, Sun Young Cho

    Clinical Laboratory
    |December 12, 2023
    PubMed
    Abstract

    Insights

    Mean platelet volume (MPV) can help differentiate bacterial from viral meningitis. Patients with bacterial meningitis had significantly higher MPV levels than those with viral meningitis in this study.

    Area of Science:

    • Neurology
    • Hematology
    • Infectious Diseases

    Background:

    • Distinguishing bacterial from viral meningitis is clinically significant.
    • Mean platelet volume (MPV) is explored as a potential biomarker.

    Purpose of the Study:

    • To investigate the utility of MPV in differentiating bacterial and viral meningitis.
    • To assess MPV levels in patients with central nervous system manifestations.

    Main Methods:

    • Blood samples were analyzed for MPV.
    • Cerebrospinal fluid analysis included bacterial culture and FilmArray ME panel.
    • MPV distribution was compared between bacterial and viral meningitis groups.

    Main Results:

    • The study included 8 bacterial meningitis and 12 viral meningitis patients.
    • Bacterial meningitis group showed a significantly higher median MPV (10.9 fL) compared to the viral meningitis group (8.4 fL).
    • The difference in MPV was statistically significant (p < 0.0001).

    Conclusions:

    • MPV may serve as a diagnostic indicator for differentiating meningitis types.
    • Further research with larger cohorts is recommended for validation.

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