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Published on: March 13, 2015
Relationship between D-Dimer to Lymphocyte Ratio and the Mortality in HBV-Associated Decompensated Cirrhosis
Background:
HBV-associated decompensated cirrhosis (HBV-DC) is hallmarked by high short-term mortality. Accurate non-invasive prognostic tools for these patients are urgent clinical need. Thus, we aimed to explore the relationship between the plasma D-dimer to lymphocyte ratio (DLR) and mortality in HBV-DC patients.
Methods:
A retrospective analysis was conducted on 152 patients with HBV-DC. To estimate disease severity and outcomes, the Model for End-Stage Liver Disease (MELD) score was utilized. The predictive value of the DLR in assessing mortality risk was assessed using multivariate logistic regression analysis and receiver operating characteristic curve analysis.
Results:
During the 30-day follow-up period, 20 patients died. The DLR was markedly different between non-survivors and survivors and higher DLR was found to be linked with adverse consequences. Furthermore, logistic regression demonstrated DLR as an independent predictive factor of 30-day mortality in HBV-DC patients and the prognostic value of DLR was very similar to that of MELD score, the combinations of DLR and MELD score show a better predictive value than that of a single index.
Conclusions:
The DLR was a reliable tool to predict 30-day mortality in HBV-DC patients.
