Related Experiment Video

Updated: Jul 8, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

2.4K

ABO blood group associated with cerebral venous thrombosis after Oxford-AstraZeneca COVID-19 vaccination: a

Gie Ken-Dror1, Pankaj Sharma1,2,

  • 1Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London TW20 0EX, UK.

Journal of the Royal Society of Medicine
|December 12, 2023
PubMed

Insights

Individuals with blood group O have a higher risk of developing vaccine-induced thrombotic thrombocytopenia (VITT-CVT) after the AstraZeneca COVID-19 vaccine. This finding suggests blood type may influence vaccine safety for cerebral venous thrombosis (CVT).

Area of Science:

  • Immunology
  • Hematology
  • Vaccinology

Background:

  • Cerebral venous thrombosis (CVT) is a rare but serious condition.
  • The AstraZeneca ChAdOx1-S vaccine has been associated with vaccine-induced thrombotic thrombocytopenia (VITT).
  • The role of blood group in VITT-CVT development requires further investigation.

Purpose of the Study:

  • To investigate the association between ABO blood groups and the risk of developing CVT after the AstraZeneca COVID-19 vaccination.
  • To determine if blood type is an independent risk factor for VITT-CVT.

Main Methods:

  • A case-control study was conducted.
  • Logistic regression analysis was used to compare blood group frequencies between vaccinated and unvaccinated CVT patients.
  • Patients were matched for age and sex.

Main Results:

  • Blood group O was significantly more prevalent in patients who developed VITT-CVT after ChAdOx1-S vaccination compared to unvaccinated controls (43% vs. 17%).
  • Blood group A was less prevalent in the vaccinated group compared to unvaccinated controls (47% vs. 71%).
  • No significant blood group differences were found in non-ChAdOx1-S vaccine VITT-CVT or pre-COVID-19 CVT groups.

Conclusions:

  • Blood group O is associated with an increased risk of VITT-CVT following ChAdOx1-S vaccination, independent of other risk factors.
  • Further research with larger datasets is needed to assess the safety of ChAdOx1-S vaccination for individuals with blood groups B and AB.
Abstract

Keywords:
ChAdOx1-S COVID-19 vaccineOxford-AstraZenecablood groupcerebral venous thrombosis

More Related Videos

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood06:33

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood

Published on: May 29, 2021

4.2K
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.4K

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
1.7K
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
567
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.7K
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.5K