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Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Related Experiment Video

Updated: Jul 8, 2025

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

The fish spleen.

Agustín G Zapata¹

¹Department of Cell Biology, Faculty of Biology, Complutense University, 28040, Madrid, Spain.

Fish & Shellfish Immunology

|December 12, 2023

Summary

This summary is machine-generated.

This study reviews fish spleen structure and function, focusing on Elasmobranchs, Teleosts, and Lungfish. Melano-macrophage centres are accumulations of macrophages due to tissue homeostasis, not primitive germinal centres.

Keywords:

Ellipsoids Fish Germinal centres Lymphoid tissues Melano-macrophage centres Spleen

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Area of Science:

Ichthyology and Comparative Immunology

Background:

The fish spleen is crucial for immune responses, with distinct histological features.
Understanding splenic structure in Elasmobranchs, Teleosts, and Lungfish is vital for comparative immunology.

Approach:

Review of existing literature on fish spleen histology and function.
Detailed examination of splenic lymphoid tissue, ellipsoids, and melano-macrophage centres.
Functional analysis of melano-macrophage centres in fish immune systems.

Key Points:

The fish spleen contains specialized structures like ellipsoids for antigen trapping.
Melano-macrophage centres are prominent features within the splenic tissue.
These centres are composed of aggregated macrophages.

Conclusions:

Melano-macrophage centres represent accumulations of macrophages related to tissue homeostasis.
The study refutes the hypothesis that these centres are primitive germinal centres.
This finding clarifies the functional significance of melano-macrophage centres in fish immunity.