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Updated: Jul 8, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Kappa what? Insights into the coordination modes of N2P2 ligands
1Department of Chemistry, Saint Olaf College, 1520 St Olaf Avenue, Northfield, Minnesota, 55057, USA. marlier@stolaf.edu.
Abstract:
While first synthesized more than three decades ago, complexes supported by N2P2 ligands have seen renewed interest due to the synthesis of new ligands, expansion of their reactivity, and catalytic applications. Possessing both soft phosphines and hard nitrogen donors, N2P2 ligands can accommodate various metal geometries and coordination modes thanks to their capability to act as bidentate, tridentate or tetradentate ligands. This short review will explore how metals bind to these ligands and also highlight the complexes' reactivity and catalytic abilities.
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