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Published on: June 20, 2018
Pediatric Renal Rickets at a Tertiary Center
Ankur Singh1, - Sucheta2, Rupal Gupta2
1Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh. Correspondence to: Dr Ankur Singh, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005. pediaankur@gmail.com.
This study details the clinical and causes of renal rickets in 19 children. Renal tubular acidosis was the most frequent cause, with genetic analysis aiding diagnosis in most cases.
Area of Science:
- Pediatrics
- Nephrology
- Genetics
Background:
- Renal rickets is a significant cause of morbidity in children.
- Understanding its clinical and etiological profile is crucial for timely diagnosis and management.
Purpose of the Study:
- To describe the clinical and etiological characteristics of pediatric patients with renal rickets.
- To evaluate the role of genetic analysis in diagnosing the underlying causes.
Main Methods:
- Retrospective analysis of 19 children diagnosed with renal rickets between 2021 and 2022.
- Clinical data collection including age, sex, and presenting symptoms.
- Etiological investigation including biochemical tests and genetic analysis for a subset of patients.
Main Results:
- The study included 19 children (10 males) with a median age of 60 months.
- Renal tubular acidosis was the most common etiology (n=8).
- Genetic analysis confirmed the diagnosis in 83% of the 6 tested subjects.
Conclusions:
- Renal rickets in children presents with diverse clinical and etiological profiles.
- Renal tubular acidosis is a leading cause, highlighting the importance of metabolic workup.
- Genetic testing is a valuable tool for identifying the underlying causes of renal rickets.
