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Disorders of the Urinary System01:20

Disorders of the Urinary System

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The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
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Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
176
Physiology of Urine Formation01:24

Physiology of Urine Formation

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Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
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Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

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Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
434
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

456
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
456
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

451
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
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Related Experiment Video

Updated: Jul 8, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

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Relationship between psoriasis and urolithiasis.

Işıl Deniz Oğuz1, Ural Oğuz2, Murat Usta3

  • 1Department of Dermatology, Giresun University School of Medicine, Giresun, Turkey.

The Journal of Dermatology
|December 13, 2023
PubMed
Summary

Patients with psoriasis have a higher risk of developing kidney stones (urolithiasis). This is linked to lower citrate and higher uric acid and sodium levels in their urine, with severity correlating to uric acid levels.

Keywords:
24-h urine analysesmetabolic disorderspsoriasisurinary stone diseaseurolithiasis

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Area of Science:

  • Nephrology
  • Dermatology
  • Urology

Background:

  • Psoriasis is a chronic inflammatory disease.
  • Urolithiasis is a common condition with multifactorial causes.
  • The association between psoriasis and urolithiasis requires further investigation.

Purpose of the Study:

  • To determine if patients with psoriasis have an increased predisposition to urolithiasis.
  • To identify potential metabolic abnormalities associated with urolithiasis in psoriasis patients.

Main Methods:

  • Prospective analysis comparing 67 psoriasis patients (PS group) with 65 non-psoriasis controls (NPS group).
  • Evaluation of 24-hour urine samples for oxalate, citrate, calcium, uric acid, magnesium, creatinine, and sodium levels.
  • Statistical analysis to compare stone event rates and metabolic parameters between groups.

Main Results:

  • A significantly higher incidence of stone events was observed in the PS group (19.4%) compared to the NPS group (7.7%).
  • Patients with psoriasis exhibited significantly lower median 24-hour urinary citrate levels and significantly higher median 24-hour urinary uric acid levels.
  • Hypernatriuria was significantly more prevalent in the PS group, and hyperuricosuria correlated with disease severity.

Conclusions:

  • Patients with psoriasis demonstrate a higher propensity for developing urolithiasis.
  • Key metabolic abnormalities in psoriasis patients include hypocitraturia, hyperuricosuria, and hypernatriuria.
  • Hyperuricosuria is associated with the severity of psoriasis, suggesting a link between disease activity and stone formation risk.