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Updated: Jul 8, 2025

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
Published on: January 19, 2019
[Immunotherapy for Lung Cancer:Current Status and Future Prospects]
1Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
Immune checkpoint inhibitors( ICI) became available in the field of non-small cell lung cancer in 2015. Nine years have already passed since their use in clinical practice, and ICI are now being developed for clinical application not only in un-resectable advanced stage lung cancer but also in peri-operative treatment. In this report, we review the history of immunotherapy and summarize the current status of clinical development of ICI in advanced lung cancer and its use as peri-operative treatment. The biomarkers analysis and management of immune-related adverse events, which are important in the treatment of ICI, will also be discussed in this review.
Immune checkpoint inhibitors( ICI) became available in the field of non-small cell lung cancer in 2015. Nine years have already passed since their use in clinical practice, and ICI are now being developed for clinical application not only in un-resectable advanced stage lung cancer but also in peri-operative treatment. In this report, we review the history of immunotherapy and summarize the current status of clinical development of ICI in advanced lung cancer and its use as peri-operative treatment. The biomarkers analysis and management of immune-related adverse events, which are important in the treatment of ICI, will also be discussed in this review.
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