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Updated: Jul 8, 2025

Author Spotlight: Accelerating Diagnostic Accuracy with Direct Identification of Gram-Negatives from Blood Culture Bottles
Published on: May 24, 2024
The impact of a blood-culture diagnostic stewardship intervention on utilization rates and antimicrobial stewardship
Melinda C Wang1, Kelvin J Zhou1, Sabra L Shay2
1Department of Medicine, Baylor College of Medicine, Houston, Texas.
Abstract:
Blood-culture overutilization is associated with increased cost and excessive antimicrobial use. We implemented an intervention in the adult intensive care unit (ICU), combining education based on the DISTRIBUTE algorithm and restriction to infectious diseases and ICU providers. Our intervention led to reduced blood-culture utilization without affecting safety metrics.
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