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Updated: Jul 8, 2025

Orthotopic Small Bowel Transplantation in Rats
Published on: November 6, 2012
[The first experience of small intestinal autotransplantation for advanced digestive cancer]
R N Komarov1, A V Egorov1, S V Osminin1
1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Abstract:
Usually, gastrointestinal tumors (GIT) invading great vessels are acknowledged to be irresectable. Along with that, we can expect positive oncological results only when there is combination treatment with radical surgery (R0 resection). In this article we share the first experience of small intestinal autotransplantation as a method of radical surgery in locally advanced GIT. We conducted the analysis of outcomes of three patients (with pancreas cancer (n=2) and neuroendocrine tumor of caecum (n=1), with neoplastic process involving to superior mesenteric artery and vein. We analyzed intraoperative aspects and algorithm of small intestinal autotransplantation. Long-term outcomes with 1.5-13 months of observing time are presented. On the basis of conducted analysis the authors suggest the possibility of small intestinal autotransplantation in referral centers with strict personalized approach and multidisciplinary surgical team.

