Related Experiment Video

Updated: Jul 8, 2025

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

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Role of YES1 signaling in tumor therapy resistance

Hai Zhou1, Dantong Sun2, Junyan Tao3

  • 1Precision Medicine Center of Oncology The Affiliated Hospital of Qingdao University Qingdao Shandong China.

Cancer Innovation
|December 13, 2023
PubMed

Insights

YES proto-oncogene 1 (YES1) drives cancer growth and resistance to chemotherapy and tyrosine kinase inhibitors (TKIs). Targeting YES1 may overcome drug resistance and improve cancer treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • YES proto-oncogene 1 (YES1) is a SRC family kinase (SFK) implicated in cancer progression.
  • YES1 amplification correlates with resistance to chemotherapy and tyrosine kinase inhibitors (TKIs) in malignancies.
  • Mechanisms underlying YES1-mediated drug resistance require further elucidation.

Purpose of the Study:

  • To review the literature on YES1 signaling in cancer.
  • To discuss the role of YES1 in chemotherapy and targeted therapy resistance.
  • To summarize recent advances in targeting YES1-amplified malignancies.

Main Methods:

  • Literature review of studies on YES1 in cancer.
  • Analysis of YES1 signaling pathways involved in drug resistance.
  • Summary of current targeted therapy approaches for YES1-amplified cancers.

Main Results:

  • YES1 contributes to cancer cell proliferation, adhesion, invasion, survival, and angiogenesis.
  • YES1 amplification is linked to resistance against chemotherapeutic drugs and TKIs.
  • Targeting YES1 presents a potential strategy to reverse drug resistance.

Conclusions:

  • YES1 signaling is a critical factor in tumorigenesis and drug resistance.
  • Targeting YES1 holds promise for overcoming resistance to conventional and targeted therapies.
  • YES1-directed therapies may represent a valuable addition to cancer treatment strategies.
Keywords:
EGFR‐TKIsYES1‐amplified malignancieschemotherapy resistancemolecular mechanisms

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