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Updated: Jul 8, 2025

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis
Pei-Ru Jheng1, Chia-Che Chiang1, Jiunn-Horng Kang1,2
1Graduate Institute of Nanomedicine and Medical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Institute of Biomedical Optomechatronics, International Ph.D. Program in Biomedical Engineering, School of Biomedical Engineering, College of Biomedical Engineering, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Abstract:
A new approach to treating vascular blockages has been developed to overcome the limitations of current thrombolytic therapies. This approach involves biosafety and multimodal plasma-derived theranostic platelet vesicle incorporating iron oxide constructed nano-propellers platformed technology that possesses fluorescent and magnetic features and manifold thrombus targeting modes. The platform is capable of being guided and visualized remotely to specifically target thrombi, and it can be activated using near-infrared phototherapy along with an actuated magnet for magnetotherapy. In a murine model of thrombus lesion, this proposed multimodal approach showed an approximately 80 % reduction in thrombus residues. Moreover, the new strategy not only improves thrombolysis but also boosts the rate of lysis, making it a promising candidate for time-sensitive thrombolytic therapy.
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