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Metabolism of Polyamines and Kidney Disease: A Promising Therapeutic Target

Dan Luo1,2, Xiaohui Lu1,2, Yi Li1,2

  • 1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Kidney Diseases (Basel, Switzerland)
|December 13, 2023
PubMed
Abstract

Insights

Chronic kidney diseases (CKD) affect millions globally, with limited treatments. This review explores polyamine metabolism

Area of Science:

  • Biochemistry
  • Pathophysiology
  • Metabolomics

Background:

  • Over 850 million individuals worldwide have acute and chronic kidney diseases (CKD), representing a significant global health burden.
  • Current therapeutic options for CKD are limited, highlighting the urgent need for understanding disease mechanisms.
  • Altered cellular metabolism is a common pathological pathway in various kidney diseases, suggesting metabolic interventions as a therapeutic strategy.

Purpose of the Study:

  • To review current knowledge on polyamine metabolism and its physiological roles.
  • To explore the potential regulatory and beneficial effects of polyamine metabolism in immunoregulation, mitochondrial homeostasis, autophagy, and DNA damage.
  • To identify polyamine metabolism as a potential therapeutic target for kidney diseases.

Main Methods:

  • Literature review of current research on polyamine metabolism.
  • Analysis of the role of polyamine metabolites (spermine, spermidine, putrescine) and their enzymes.
  • Examination of polyamine metabolism's involvement in physiological processes and disease pathology.

Main Results:

  • Polyamine metabolism is an endogenous regulator of cellular metabolism and a potential therapeutic target.
  • Polyamines play roles in immunoregulation, mitochondrial function, autophagy, and DNA repair.
  • Dysregulation of polyamine metabolism is implicated in the progression of kidney diseases.

Conclusions:

  • Polyamine metabolism represents a promising novel therapeutic avenue for kidney diseases.
  • Understanding polyamine pathways could lead to new strategies for preventing and slowing CKD progression.
  • Targeting polyamine metabolism may offer a new approach to managing the socioeconomic burden of kidney disease.
Keywords:
Kidney diseasePolyaminesSpermidineSpermineTherapeutic potential

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