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Host cellular factors involved in pseudorabies virus attachment and entry: a mini review

Lei Tan1,2, Kaixin Wang2, Ping Bai3

  • 1College of Animal Science, Yangtze University, Jingzhou, China.

Frontiers in Veterinary Science
|December 13, 2023
PubMed

Insights

Pseudorabies virus (PRV) infects mammals and humans, acting as a zoonotic pathogen. Understanding cellular factors in PRV attachment and entry is key to developing new antiviral treatments.

Area of Science:

  • Virology
  • Cell Biology
  • Infectious Diseases

Background:

  • Pseudorabies virus (PRV), an Alphaherpesvirinae, models Herpes simplex virus type 1 infections.
  • PRV exhibits zoonotic potential, infecting diverse mammals, including humans.

Purpose of the Study:

  • To summarize cellular factors involved in PRV attachment and entry.
  • To guide the development of novel antiviral agents against PRV.

Main Methods:

  • Literature review of current research on PRV-host cell interactions.
  • Analysis of cellular factors mediating PRV infection stages.

Main Results:

  • Identified key cellular factors critical for PRV attachment.
  • Detailed the mechanisms of PRV entry into host cells.
  • Highlighted the significance of these factors in viral pathogenesis.

Conclusions:

  • Cellular factors play a vital role in PRV infection.
  • Targeting these factors offers a promising strategy for antiviral drug development.
Keywords:
antiviral strategiescellular factorsinvolvementpseudorabies virusviral attachment and entry

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