Clinimetric properties of the Perme Intensive Care Unit Mobility Score -a multicenter study for minimum important...

Area of Science:

• Clinical assessment and measurement
• Intensive care unit (ICU) outcomes
• Patient mobility evaluation

Background:

• Validated instruments are crucial for accurate patient assessment and outcome measurement in clinical settings.
• The Perme Intensive Care Unit Mobility Score (Perme Score) is utilized for assessing mobility in critically ill patients.
• Establishing the psychometric properties of clinical instruments enhances their reliability and utility.

Purpose of the Study:

• To determine the minimum clinically important difference (MCID) for the Perme Score.
• To evaluate the responsiveness of the Perme Score to changes in patient mobility.
• To assess other clinimetric properties including floor/ceiling effects, internal consistency, and predictive validity of the Perme Score.

Main Methods:

• Retrospective, multicentric study involving 1,200 adult patients from four ICUs.
• Receiver Operating Characteristic (ROC) curve analysis was used to estimate the MCID.
• Hosmer and Lemeshow goodness-of-fit test was employed for ROC curve calibration.

Main Results:

• An area under the curve (AUC) of 0.96 indicated strong performance in identifying clinically relevant mobility changes.
• An optimal cut-off value of 7.0 points was established for the Perme Score's MCID.
• The Perme Score demonstrated good predictive validity for hospital mortality and ICU length of stay, with minimal floor/ceiling effects at discharge.

Conclusions:

• The study successfully established the MCID and responsiveness of the Perme Score.
• Findings support the Perme Score's utility as a reliable measure of mobility status in the ICU.
• The established clinimetric properties enhance confidence in using the Perme Score for patient management and research.