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Long non-coding RNA and Evolving drug resistance in lung cancer

Meibin Wang1, Yujie Fu2, Chuyue Zhong3

  • 1The Dingli Clinical college of Wenzhou Medical University, Wenzhou 325000, PR China.

Heliyon
|December 13, 2023
PubMed

Insights

Long noncoding RNAs (lncRNAs) significantly contribute to non-small cell lung cancer (NSCLC) therapy resistance. This review summarizes how lncRNAs mediate resistance to chemotherapy and targeted drugs in NSCLC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) presents high incidence and mortality rates globally.
  • Platinum-based chemotherapy and targeted therapies offer benefits to advanced NSCLC patients.
  • Therapy resistance, both primary and acquired, leads to treatment failure and tumor progression in NSCLC.

Purpose of the Study:

  • To systematically review the mechanisms of lncRNA-mediated resistance to chemotherapy in NSCLC.
  • To elucidate the role of lncRNAs in mediating resistance to targeted therapy drugs in NSCLC.
  • To provide a comprehensive summary of lncRNA functions in NSCLC drug resistance.

Main Methods:

  • Literature review of studies investigating lncRNAs and drug resistance in NSCLC.
  • Systematic summarization of identified mechanisms.
  • Analysis of lncRNA involvement in chemotherapy and targeted therapy resistance.

Main Results:

  • Long noncoding RNAs (lncRNAs) are critically involved in NSCLC development.
  • lncRNAs play a vital role in mediating resistance to both chemotherapy and targeted therapy.
  • Multiple complex mechanisms underlie lncRNA-mediated drug resistance in NSCLC.

Conclusions:

  • lncRNAs are key regulators of drug resistance in non-small cell lung cancer.
  • Understanding lncRNA-mediated resistance mechanisms is crucial for overcoming treatment failure.
  • Targeting lncRNAs may offer novel therapeutic strategies for overcoming NSCLC drug resistance.
Keywords:
CisplatinDrug resistanceEpidermal growth factor receptor tyrosine kinase inhibitorsLong non-coding RNANon-small cell lung cancerTaxanes

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