Related Experiment Video
Updated: Jul 8, 2025
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
Published on: March 7, 2017
Malignant transformation of desmoplastic infantile tumors in a non-infant: a case report
Yan Yang1, Bin Tian1, Xuzhu Chen2
1Department of Radiology, The Second People's Hospital of Guiyang, Guiyang, China.
Insights
This case report details a rare instance of desmoplastic infantile tumors (DITs) transforming into glioblastoma multiforme, leading to metastasis. It highlights the critical need for vigilance regarding potential malignant changes in DITs.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Pathology
Background:
- Desmoplastic infantile tumors (DITs) are rare intracranial neoplasms typically exhibiting benign behavior in infants.
- Malignant transformation of DITs is exceptionally uncommon, making such cases significant for understanding tumor progression.
Observation:
- A 6-year-old girl with DITs underwent initial surgical resection.
- The tumor recurred 12 years later, with pathology confirming malignant transformation to glioblastoma multiforme.
- The patient subsequently developed intraspinal metastasis and multiple spinal cord metastases.
Findings:
- This case demonstrates a late-stage malignant transformation of DITs into glioblastoma multiforme.
- The progression involved cranial recurrence, followed by extensive intraspinal and spinal cord metastasis.
- Imaging studies (CT and MRI) were crucial in assessing the tumor's transformation and spread.
Implications:
- Highlights the potential for desmoplastic infantile tumors to undergo malignant transformation, even years after initial diagnosis.
- Underscores the importance of long-term surveillance for patients with DITs due to the risk of aggressive recurrence and metastasis.
- Suggests a need for further research into the mechanisms driving DIT malignant transformation and metastasis.
Abstract:
Desmoplastic infantile tumors (DITs) are rare benign intracranial tumors in infants with benign biological behavior and rare malignant transformation characteristics. We present a DIT case that underwent malignant transformation and metastasis. A 6-year-old girl presented with DITs and underwent surgical resection. 12 years later, the tumor recurred and underwent surgical resection again. The pathology report confirmed the lesion to be a glioblastoma multiforme. She received adjuvant treatment. A year after the surgical operation of the lesions, she had intraspinal metastasis and underwent surgical resection again. Multiple spinal cord metastases were subsequently identified in the patient. The patient's condition exhibited severe deterioration during the follow-up period. This case report focuses on the occurrence of DITs and their potential malignant transformation, as assessed through computed tomography and magnetic resonance imaging.
More Related Videos
10:58Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
Published on: February 22, 2015
08:57Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
02:23Abnormal Proliferation
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...