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Lactobacillus paracasei R3 Alleviates Tumor Progression in Mice with Colorectal Cancer.

Tao Chen1, Baoxia Li1, Kangdi Zheng1

  • 1Center of Human Microecology Engineering and Technology of Guangdong Province, Guangdong Longsee Biomedical Corporation, Guangzhou, 510535, Guangdong, China.

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|December 13, 2023
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Summary
This summary is machine-generated.

Lactobacillus paracasei R3 (L.p R3) is a safe, non-hemolytic probiotic with moderate biofilm ability. This strain shows potential for preventing and treating colorectal cancer in mice.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Probiotics

Background:

  • Lactobacillus paracasei (L. paracasei) is a widely used probiotic with varied strain-specific properties.
  • Strain differences in L. paracasei impact functionality, colonization resistance, and physicochemical traits.
  • Characterizing specific strains is crucial for identifying suitable candidates for probiotic applications.

Purpose of the Study:

  • To evaluate the characteristics of Lactobacillus paracasei R3 (L.p R3) isolated from human feces.
  • To determine if L.p R3 meets the criteria for an edible probiotic.
  • To assess the in vitro and in vivo probiotic activity traits of L.p R3.

Main Methods:

  • In vitro assays for hemolysis, biofilm formation, antibiotic susceptibility, and toxicity.
  • In vivo toxicity assessment in mice, monitoring body weight, growth, and organ health.
  • Evaluation of L.p R3 efficacy in colorectal cancer prevention and treatment models in mice.

Main Results:

  • L.p R3 exhibited moderate biofilm formation and was non-hemolytic.
  • The strain demonstrated sensitivity to 11 antibiotics and resistance to eight.
  • Toxicity assays in mice revealed no adverse effects on body weight, growth, or organ function.
  • L.p R3 showed efficacy in preventing and treating colorectal cancer in a mouse model.

Conclusions:

  • Lactobacillus paracasei R3 (L.p R3) is a safe edible probiotic candidate with no observed toxic side effects.
  • L.p R3 demonstrated potential in alleviating colorectal cancer progression in mice.
  • Further research into L.p R3 could support its application in functional foods and therapeutic strategies.