[Plasma level of testosterone-estradiol-binding globulin in women with Itsenko-Cushing disease]

A total of 50 patients with Icenko-Cushing's disease were examined for the levels of estradiol, testosterone and testosterone-binding globulin in various stages of the disease. In disease recurrences the levels of testosterone were two-fold higher than those in normal subjects versus the testosterone-estradiol-binding capacity (TEBC) in the blood serum which was decreased in patients with Icenko-Cushing's disease. During remission the levels of testosterone decreased, those of the blood TEBC increased, but however failed to achieve their values in health. Normalization of the above mentioned levels followed a total adrenalectomy. The levels of TEBC and testosterone were in a feedback correlation whereas no correlation was recorded between the levels of estradiol and TEBC. The TEBC levels estimation can be used for the assessment of the disease clinical course.