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Aortic ascorbic acid, trace elements, and superoxide dismutase activity in human aneurysmal and occlusive disease
Summary
Atherosclerotic cardiovascular disease is linked to altered trace elements and ascorbic acid. This study found higher iron and manganese, but lower zinc:copper ratios and reduced superoxide dismutase activity in diseased aortic tissues.
Area of Science:
- Biochemistry
- Cardiovascular Biology
- Trace Element Metabolism
Background:
- Atherosclerotic cardiovascular disease pathogenesis involves trace elements and ascorbic acid.
- The specific roles of these elements and ascorbic acid in disease progression and plaque formation are not well understood.
Purpose of the Study:
- To investigate trace element (Fe, Cu, Zn, Mn) and ascorbic acid concentrations, and superoxide dismutase (SOD) activity in patients with abdominal aortic aneurysms (AAA) and atherosclerotic occlusive disease (AOD).
- To explore the relationship between these factors and the development of aortic diseases.
Main Methods:
- Analysis of Fe, Cu, Zn, Mn concentrations, ascorbic acid levels, and SOD activity in aortic tissue samples from AAA, AOD, and control groups.
- Comparison of trace element ratios, including Zn:Cu and Cu,Zn-SOD:Mn-SOD, between diseased and control tissues.
Main Results:
- Elevated Fe and Mn concentrations were observed in AAA and AOD tissues compared to controls.
- Zn:Cu ratio was significantly lower in AAA tissue than in AOD and control tissues.
- AAA and AOD tissues exhibited reduced ascorbic acid levels and Cu,Zn-SOD activity, with significantly altered Cu,Zn-SOD:Mn-SOD ratios.
Conclusions:
- Aorta affected by aneurysms and occlusive disease show altered trace element and ascorbic acid profiles.
- Low Cu,Zn-SOD activity suggests a potential role for oxygen radicals or lipid peroxidation in the pathogenesis of these aortic conditions.
- Findings do not confirm aortic copper deficiency in AAA but highlight metabolic alterations in diseased aorta.