Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

143
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
143
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

180
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
180

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinicopathologic characteristics of uterine malignant epithelioid neoplasms with EWSR1::CREM fusion: Report of 2 cases at a novel site with literature review.

Virchows Archiv : an international journal of pathology·2026
Same author

Analysis of changes in glomerular lesions in children diagnosed with IgA nephropathy following immunosuppressive therapy.

BMC nephrology·2026
Same author

CD71 as an independent prognostic factor in pediatric B-ALL: a regional multicenter retrospective study in Southern China (SCCLG-ALL-2016).

Therapeutic advances in medical oncology·2026
Same author

A case report of congenital sideroblastic anemia caused by a novel ALAS2 mutation in conjunction with thalassemia.

Annals of hematology·2026
Same author

<i>Treponema pallidum</i> Impairs Microglial Aβ<sub>1</sub><sub>-</sub><sub>4</sub><sub>2</sub> Clearance by Hijacking TLR2/PI3K/AKT Immune Signaling.

ACS infectious diseases·2026
Same author

Remote ischemic conditioning combined with transcutaneous vagus nerve stimulation reduces reperfusion injuries and improves cardiac function in acute ST-segment elevation myocardial infarctions.

BMC cardiovascular disorders·2026

Related Experiment Video

Updated: Jul 8, 2025

Author Spotlight: Advancing Syphilis Research &#8212; Innovations in Treponema pallidum Cultivation and Genetic Engineering
09:45

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

3.8K

A 4-fold or greater decrease in TPPA titers may indicate effective BPG treatment in primary syphilis.

Yun-Ting Hu1, Jia-Bin Wu2, Miao-Hui Zhuang3

  • 1Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian Province, China.

International Immunopharmacology
|December 13, 2023
PubMed
Summary
This summary is machine-generated.

A four-fold decrease in Treponema pallidum particle agglutination (TPPA) titers may indicate effective syphilis treatment. Combining TPPA and rapid plasma reagin (RPR) titers could aid early syphilis diagnosis.

Keywords:
SyphilisTreatment efficacy monitoringTreponema pallidumTreponema pallidum particle agglutination

More Related Videos

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
11:00

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Published on: August 31, 2015

8.3K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.1K

Related Experiment Videos

Last Updated: Jul 8, 2025

Author Spotlight: Advancing Syphilis Research &#8212; Innovations in Treponema pallidum Cultivation and Genetic Engineering
09:45

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

3.8K
Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
11:00

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Published on: August 31, 2015

8.3K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.1K

Area of Science:

  • Infectious Diseases
  • Immunology
  • Microbiology

Background:

  • The treponema pallidum particle agglutination (TPPA) test offers higher specificity than the rapid plasma reagin (RPR) test for syphilis diagnosis.
  • The utility of TPPA for serological monitoring post-syphilis therapy remains debated.

Purpose of the Study:

  • To assess the suitability of TPPA titers for monitoring the efficacy of syphilis treatment.

Main Methods:

  • Recruited 232 primary syphilis patients for serological testing at baseline and 6 months post-treatment with benzathine penicillin G (BPG).
  • Utilized a rabbit model infected with Treponema pallidum (T. pallidum) to evaluate TPPA titer changes after BPG therapy.
  • Compared TPPA titers in splenocyte culture supernatants stimulated with T. pallidum, with and without BPG.

Main Results:

  • 150 (64.7%) of 232 patients achieved serological cure after 6 months; 82 (35.3%) had adverse outcomes.
  • A >4-fold decrease in TPPA titers correlated with serological cure (109/110 patients, P < 0.0001).
  • In rabbits, BPG treatment significantly decreased TPPA titers (P = 0.016), while untreated rabbits maintained or increased titers.

Conclusions:

  • A ≥4-fold reduction in TPPA titers suggests effective treatment for primary syphilis.
  • Integrating TPPA and RPR titers may enhance early syphilis diagnosis and monitoring.