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Updated: Jul 8, 2025

Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry
Published on: June 22, 2017
A maelstrom of migrating monocytes drives neurodegeneration
Nicole G Coufal1, Michelle L Hermiston2
1Department of Pediatrics, University of California, San Diego, San Diego, CA, USA.
Abstract:
Neurodegeneration is a devastating complication of Langerhans cell histiocytosis (LCH), but it is not clear how it develops. In this issue of Immunity, Wilk et al. demonstrate that circulating BRAFV600E+ myeloid cells damage the blood-brain barrier and infiltrate the brain. Dual inhibition of the MAPK and senescence pathways can block parenchymal injury, providing a potential therapeutic avenue for histiocytic neurodegeneration.
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